Nanotechnology Healthcare

Redefining cancer treatment through nanotechnology

Orinova develops innovative drug candidates using exclusive nanotechnology to target tumors with unprecedented precision, without harming healthy tissue.



About us

Based in Besançon, ORINOVA is a biotechnology company focused on developing first-in-class product candidates that use proprietary nanotechnology to transform cancer treatment.

ORINOVA develops disruptive nanotherapeutics with the potential to tackle the solid tumors from different angles and designed for many localized cancers.

ORINOVA is developing nanotherapeutics to patients with hard-to-treat localized cancers such as glioblastoma (GBM).

ORINOVA is also to improve survival in cancer by reducing treatment toxicities to patients with solid tumors such as rectal cancers.

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Our mission

At ORINOVA, we are translating years of basic academic research in the field of nanomedicines into novel therapeutic approaches to treat cancers.

We specialize in the development of first-in-class nanomedicines combining chemotherapy and radiotherapy from local delivery to global impact on the tumor.

Our history

Key value-creating milestones

September 2024

January 2025

2025

October 2025

A complementary team

Jean-Marc Zeil - PDG & cofondateur

Jean-Marc Zeil

CEO & co-founder

CEO of pharma and food industries for +20y.

Business development

Strong growth of the various companies managed

Claudine Vermot-Desroches Directrice scientifique et cofondatrice

Claudine Vermot-Desroches

CSO & co-founder

Immunotherapies Expert in Oncology for +25y. - Drug discovery - Translational R&D

4 Licenses to Pharma

+50 publications / +25 patents

Tristan Doussineau DMO

Tristan Doussineau

DMO

Nanomedicine development expert

+8 years in clinical-stage

GMP nanodrug batch release

+45 publications / 1 patent

Board GBM

  • Dr Frédéric Dhermain Radiotherapiste IGR

    Dr Frédéric Dhermain

    Radiotherapist IGR

  • Dr Bertrand Mathon Neurochirurgien La Pitié Salpêtrière

    Dr Bertrand Mathon

    Neurosurgeon - La Pitié Salpêtrière

  • Dr Mehdi Touat Neuro-oncologiste La pitié Salpêtrière

    Dr Mehdi Touat

    Neuro-oncologist - La pitié Salpêtrière

  • Prof Gilles Truc Radiotherapiste CGFL

    Prof Gilles Truc

    Radiotherapist - CGFL

Board Anorectal Cancer

  • Prof Michel Ducreux PUPH, Chef de Service Oncologie digestive Institut Gustave Roussy

    Prof Michel Ducreux

    PUPH, Head of the Digestive Oncology Department – Gustave Roussy Institute

  • Prof Thomas Aparicio PUPH, Oncologie Digestive Hôpital Saint-Louis

    Prof Thomas Aparicio

    PUPH, Oncologie Digestive - Saint-Louis Hospital

Our technology

Notre technologie - image d'illustration
The problem

Chemotherapy or radiotherapy a cornerstone of cancer treatment, but are reaching their limits. We cannot increase efficacy without increasing toxicity, this is the core limitation

The solution

The arrival of nanobiotechnologies in oncology brings a new breath of hope to cancer treatment. ORINOVA’s proprietary platform is suitable for intratumoral delivery that transforms radio-chemotherapy into a high-efficacy, low-toxicity treatment.


Multifonctional nanomedicine is gaining momentum to tackle by different modes of action at the same time in the heart of the tumor. Our approach allows approved cancer treatments to work more efficiently and further improve outcomes for patients.

All the benefits of the RAD-CHEM-X™ platform  
Pictos pour Développement de nanothérapies innovantes

Development of First-in-Class Nanotherapeutics

Picto pour Augmentation de la dose de rayonnement délivrée à la tumeur sans augmenter la dose reçue par les tissus sains

Increasing the radiation dose delivery to the tumour without increasing the dose to healthy tissue

Picto pour Administration simultanée d'une chimiothérapie au cœur de la tumeur

Codelivery of chemotherapy and radioenhancer in the same time in the heart of the tumour

Picto pour Avec le potentiel de dépasser les limites des traitements spécifiques à la biologie

With the potential to transcend the limitations of biology-specific treatments

Picto pour Rapidement adaptable et modulable pour bénéficier à un large éventail de patients

Swiftly adapted and scaled to benefit a diverse range of patients

Picto pour Disponible pour différents types de cancer

Available for different cancer types

A multimodality nanoplatform (RAD-CHEM-X™) designed for local precision cancer therapy

Schema - A multimodality nanoplatform (RADCHM-X) desgined for local precision cancer therapy Schema - A multimodality nanoplatform (RADCHM-X) desgined for local precision cancer therapy

Oncology focus

We are developing a novel class of nanomedicine-based therapies to address severe medical need in oncology.
The selected indications simultaneously meet two clear eligibility filters.
  • 1

    Chemoradiotherapy is already integrated into current treatment

  • 2

    The tumor is accessible for intra-tumoral injection

Orinova schéma anatomie
For Glioblastoma
  • Current GBM treatments offer poor survival benefit, with high rates of recurrence.

  • With efficacious modality but with some limitations

  • Patient’s quality of life is impacted by symptoms, progression and treatment side effects

For Rectal Cancer
  • Colorectal cancer is the third leading cause of cancer death worldwide.

  • Rectal cancer accounts for 30% of all colorectal cancers.

  • An emerging need: preventing radiation toxicity.

  • Adverse effects of radiotherapy include intestinal and rectal inflammation.

  • Later toxicity, such as neurotoxicity, can also occur in patients receiving combined chemotherapy.

Pipeline

Our therapeutic candidates
ORI-101
Design of ORI-nanotherapeutics (undisclosed Target Product Profile)
Learn more about ORI-101
A nanotherapeutic (100 nm) containing :
  • A high number of Gold (Au) atoms used as radiotherapy enhancer.

  • Some chelated gadolinium (Gd) atoms, enabling contrast during IRM

  • Paclitaxel with binds to tubulin, stabilize the microtubule structure, which prevents cell division and ultimately leading to cancer cell death

Thanks to RAD-CHEM-X™ nanotechnology platform
  • To improve PTX pharmaceuticals’ solubility

  • To bypass BB penetration following intra tumoral administration

  • To improve tumor accumulation and reduce off-target toxicity

portrait-middle-aged-woman-with-skin-cancer
ORI-101 : Key value drivers and clinical differentiation
  • New generation of nanomedicines to patients with hard-to-treat brain tumors such as glioblastoma (GBM).

  • Delivery in the heart of the tumor

  • With broad application for solid tumors such as renal cancers,…

  • Maximizing the dose in the tumor, minimizing the systemic exposure

  • Local multimodality nanomedicine through

  • Paclitaxel triggered tumor cell death

  • Increasing the radiation dose delivery to the tumour without increasing the dose to healthy cells

  • Tumor microenvironment modulation

  • Designed to disrupt outcomes without disrupting clinical practice

  • Currently in the final stages of non-regulatory preclinical development with process with FIH in 2029

Our impacts

Positive environmental impacts

Our technology aligns perfectly with the UN’s SDG 3 on sustainable development: “Ensure healthy lives and promote well-being for all at all ages.”

Indeed, ORINOVA technology optimizes the treatment of GBM and localized solid tumors in general, notably allowing for reduced doses of radiation therapy and chemotherapy while ensuring that all active agents are delivered to the target area.

These advantages help reduce the energy footprint of medical infrastructure related to radiation production and administration (electricity consumption, equipment runtime) and limit the production of chemotherapy drugs and chemicals in general. Furthermore, we contribute to a more efficient use of medical resources by reducing losses and waste associated with ineffective treatments.

Thus, ORINOVA has a positive impact on the environment by reducing the use of terrestrial resources compared to current treatments, limiting industrial emissions and discharges and thereby reducing pollution, and finally, indirectly mitigating climate change.

Positive societal impacts

ORINOVA aims to provide an innovative new treatment for glioblastoma and other types of solid tumors, such as rectal cancer, thereby extending patients’ lives and improving their comfort during treatment, particularly by reducing side effects.

ORINOVA addresses an unmet medical need: the treatment of glioblastoma. Glioblastoma, an orphan disease, is a highly aggressive and invasive solid tumor located in the brain.

Expectations are high; the standard of care has not evolved in some twenty years, and despite significant research funding, no Phase 3 clinical trial to date has identified a promising candidate.

Tens of thousands of patients with glioblastoma could then see their life expectancy increase with greater comfort (fewer side effects), and eventually millions of people once our treatment is applied to other cancers.

News

Orinova wins the i-Lab Grand Prix 2025

Orinova wins the i-Lab Grand Prix 2025

i-Lab Grand Prix 2025 is a highly selective innovation competition organized by France 2030 and the BPI… And Orinova won !

Read more
Orinova proof of concept.

Orinova proof of concept.

Two highly conclusive in vivo proof-of-concept (POC) studies on glioblastoma, including one comparing the treatment to the STUPP protocol, the standard of care.

Read more

Contact

To contact us, please send us an email.

Address

Temis Innovation Technopole
18 rue Alain Savary, 25000 Besançon